Polynucleotide Phosphorylase Stops Replication Restart by Degrading the RNA within R-loops during Replication-Transcription Conflicts
Oyku Sensoy, Juan Carvajal-Garcia, Shahin Boumi, Houra Merrikh
The paper shows that PNPase degrades RNA in R-loops to prevent replication restart and reduce mutations during replication-transcription conflicts.
bioRxiv · Jun 3, 2026 · PreprintGenetics