Rewiring DNA Repair Activity into CRISPR Signal Transduction via Synthetic DNA Transducers
Neda Bagheri, Alessandro Bertucci, Rosa Merlo, Alessandro Porchetta
This paper introduces a synthetic DNA transduction platform that links DNA repair activity to CRISPR-Cas12a activation, enabling rapid and sensitive detection of DNA glycosylase activity and inhibitor screening.
bioRxiv · Jul 11, 2025 · PreprintSynthetic Biology