Author

Raphael Kuhn

ETH ZurichORCID 0000-0002-4068-2048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexander YermanosiD· 2 shared Andreas AgrafiotisiD· 2 shared Danielle ShlesingeriD· 2 shared Sai T. ReddyiD· 2 shared Alessandro Genovese· 1 shared Annette OxeniusiD· 1 shared Camilla Panetti· 1 shared Daphne van GinnekeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersImmunology

Alexander YermanosORCID

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2 papers

Recent·Most cited

Dissecting serum polyclonal antibody escape to SARS-CoV-2 variants by deep mutational learning

Danielle Shlesinger, Viktor Sadílek, Mason Minot, Evangelos Stamkopoulos, Thomas Bikias, Raphael Kuhn, Andreas Agrafiotis, Joseph M. Taft, Alexander Yermanos, Sai T. Reddy

The paper uses deep mutational learning to analyze serum antibody escape to SARS-CoV-2 variants, finding individualized escape profiles and conserved binding signatures.

Cell Reports Methods · Apr 23, 2026Peer-reviewedImmunology

Clonally expanded IgG antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections

Andreas Agrafiotis, Raphael Kuhn, Camilla Panetti, Marco Venerito, Hathaichanok Phandee, Lucas Stalder, Danielle Shlesinger, Vittoria Martinolli D’Arcy, Kai‐Lin Hong, Daphne van Ginneken, Alessandro Genovese, Nicole Joller, Annette Oxenius, Sai T. Reddy, Alexander Yermanos

The paper characterizes clonal dynamics of antibody-secreting cells in bone marrow following influenza infection, finding that IgG ASCs preferentially target nucleoprotein regardless of infection type.

The Journal of Immunology · Jul 26, 2025Peer-reviewedImmunology