Nicole Joller

This study shows that exhausted CD8 T cells can produce IFN-gamma in response to IL-12 and IL-18, indicating retained cytokine-driven effector capacity.

The paper identifies a fibroblast-IL-7 feedback loop that promotes immunosuppressive monocyte-derived cells, which restrain CD4+ T cell responses during infection.

This study shows IL-12R signaling sustains T-bet in Treg cells, promoting type 1 specialization and enhancing suppressive function against Th1 responses.

The paper characterizes clonal dynamics of antibody-secreting cells in bone marrow following influenza infection, finding that IgG ASCs preferentially target nucleoprotein regardless of infection type.

The paper shows that CD4 T cells can acquire TCR-independent IFN-gamma production capabilities through TCR and CD28 stimulation, suggesting a broader role in immune responses.

This study shows that chronic antigen exposure leads to T cell exhaustion, reducing the effectiveness of T cell bispecific therapies in solid tumors.