Structural basis for Porcupine inhibition
Katrina A. Black, Jesse I. Mobbs, Hariprasad Venugopal, Toby A. Dite, Andrew P. Leis, Lilian L. L. Wong, Laura F. Dagley, David M. Thal, Alisa Glukhova
This paper presents cryo-EM structures of PORCN with inhibitors, revealing a conserved water-mediated binding mechanism for rational drug design.
Communications Chemistry · Nov 12, 2025Peer-reviewedBiochemistry