Author

Howard Brett

Thames Water (United Kingdom)ORCID 0000-0002-4100-8565Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:metagenomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Ann Sarah WalkeriD· 2 shared DS Read· 2 shared J Hughes· 2 shared KK Chau· 2 shared Nicole E StoesseriD· 2 shared Tim GoodalliD· 2 shared Bede ConstantinidesiD· 1 shared David W. EyreiD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenomics

Ann Sarah WalkerORCID

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2 papers

Recent·Most cited

High-resolution characterisation of short-term temporal variability in the taxonomic and resistome composition of wastewater influent

KK Chau, Tim Goodall, Michael J. Bowes, Karen Easterbrook, Howard Brett, J Hughes, Derrick W. Crook, DS Read, Ann Sarah Walker, Nicole E Stoesser

This study compares taxonomic and resistome variability between single-timepoint grab and 24H-composite wastewater samples, finding that composites better capture AMR genes and reduce temporal variability.

bioRxiv · Jul 8, 2022 · PreprintGenomics

Evaluation of metagenomic, 16S rRNA gene and ultra-plexed PCR-based sequencing approaches for profiling antimicrobial resistance gene and bacterial taxonomic composition of polymicrobial samples

KK Chau, William Matlock, Bede Constantinides, Samuel Lipworth, Lindsay K. Newbold, Holly J. Tipper, Tim Goodall, Howard Brett, J Hughes, DW Crook, David W. Eyre, DS Read, Ann Sarah Walker, Nicole E Stoesser

The paper evaluates metagenomic, 16S rRNA gene, and ultra-plexed PCR-based sequencing methods for taxonomic and AMR gene profiling in polymicrobial samples, finding that AmpliSeq and shotgun metagenomics perform best for resistome profiling.

bioRxiv · May 12, 2022 · PreprintGenomics