William Matlock

The paper investigates how plasmid mobility affects GC content evolution in bacterial hosts, finding that plasmid lineage and transmission dynamics, rather than host phylogeny, drive compositional similarity.

The paper quantifies host-lineage restriction of plasmid backbones in E. coli isolates and shows how this restriction structures plasmid co-occurrence.

This study shows that combining DNA-damaging agents with antibiotics can reduce resistance evolution in specific hypermutator bacterial genotypes but not others.

The paper shows that E. coli phylogeny influences blaTEM-1 expression and co-amoxiclav resistance through lineage-specific regulatory differences.

The paper analyzes 2,559 E. coli plasmids to show that antibiotic resistance genes and phage defense systems are physically linked, suggesting potential interactions between antibiotic use and phage therapy.

The paper analyzes the global genomic diversity of blaGES-5 integrons using a pangenome graph-based workflow, revealing differences between chromosomal and plasmid-associated integrons.

A uniformly processed set of 2,440,377 bacterial and archaeal genomes with search tools and annotations, plus an AI-mined peptide set yielding ATB20, active in a mouse skin infection model.

The paper investigates plasmid sharing among Enterobacterales in human infections, livestock, wastewater, and waterways in Oxfordshire, finding shared plasmid backbones and rapid accessory gene changes across niches.

The paper evaluates metagenomic, 16S rRNA gene, and ultra-plexed PCR-based sequencing methods for taxonomic and AMR gene profiling in polymicrobial samples, finding that AmpliSeq and shotgun metagenomics perform best for resistome profiling.

Flanker clusters gene flanking sequences to identify mobile genetic element patterns associated with antimicrobial resistance genes.

The paper analyzes IncF plasmid diversity across environmental and livestock settings using network community analysis, revealing niche-driven partitioning and core gene-defined communities.