NeurosciencebioRxivPreprint
AAV-based temporal APOE4-to-APOE2 replacement reveals rebound adaptation and RAB24-mediated Aβ and cholesterol dysregulation
Ruihan Yang, Yue Li, Xingchen Zhao…·Jian Sima
This study uses AAV-based gene therapy to replace APOE4 with APOE2 in mice, revealing that long-term replacement reverses AD pathology while short-term replacement worsens it, with RAB24 playing a key role.
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