BioinformaticsbioRxivPreprint
Defining the Active Conformation of Typical Protein Kinase Domains from Substrate-Bound PDB Structures Enables Active-State AlphaFold2 Models for All 437 Human Catalytic Protein Kinases
Joan Gizzio, Bulat Faezov, Qifang Xu, Roland L. Dunbrack
The paper defines structural criteria for the active form of human protein kinases using substrate-bound structures and uses AlphaFold2 to generate active-state models for all 437 human catalytic kinases.
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