Bulat Faezov

De novo design of selective kinase modulators

This study designs genetically encoded miniproteins to modulate FAK kinase activity, showing they can inhibit or activate FAK in vitro and in cells, and adapt them to target other kinases.

Defining the Active Conformation of Typical Protein Kinase Domains from Substrate-Bound PDB Structures Enables Active-State AlphaFold2 Models for All 437 Human Catalytic Protein Kinases

The paper defines structural criteria for the active form of human protein kinases using substrate-bound structures and uses AlphaFold2 to generate active-state models for all 437 human catalytic kinases.

AlphaFold2 models of the active form of all 437 catalytically-competent typical human kinase domains

With active-state templates and shallow ortholog alignments, AlphaFold2 models all 437 human catalytic kinase domains as active; 80% of 130 benchmarked kinases are under 1 Å activation-loop RMSD.

FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55/PP2A phosphatase

This paper identifies FAM122A as a SLiM-dependent inhibitor of B55/PP2A that competes with substrates to regulate cell cycle progression and checkpoint control.

PDBrenum: a webserver and program providing Protein Data Bank files renumbered according to their UniProt sequences

PDBrenum renumbers PDB files to align with UniProt sequences, resolving inconsistent amino acid numbering across PDB entries.