Author

Valentina Sanghez

The Lundquist InstituteORCID 0000-0002-4131-7480Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Michelina IacovinoiD· 2 shared Angelina S Norris· 1 shared Anna LuzziiD· 1 shared Callan L BuechsenschuetziD· 1 shared Don ClarkeiD· 1 shared Geoffrey G. HicksiD· 1 shared H. Daniel PereziD· 1 shared Ivy PhamiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Michelina IacovinoORCID

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2 papers

Recent·Most cited

Genetically corrected iPSC-derived Neural Stem Cell Grafts deliver NAGLU-IGFII fusion protein to affect CNS disease in Sanfilippo B Mice

Yewande Pearse, Don Clarke, Shih‐hsin Kan, Steven Q. Le, Valentina Sanghez, Anna Luzzi, Ivy Pham, Lina R. Nih, Jonathan D. Cooper, Patricia Dickson, Michelina Iacovino

This study genetically corrects iPSC-derived neural stem cells to deliver a modified NAGLU enzyme, reducing disease pathology in Sanfilippo B mice.

bioRxiv · Jun 30, 2022 · PreprintNeuroscience

A novel, ataxic mouse model of Ataxia Telangiectasia caused by a clinically relevant nonsense mutation

H. Daniel Perez, May F. Abdallah, Jose I Chavira, Angelina S Norris, Martin T. Egeland, Karen L. Vo, Callan L Buechsenschuetz, Valentina Sanghez, Jeannie L Kim, Molly Pind, Kotoka Nakamura, Geoffrey G. Hicks, Richard A. Gatti, Joaquı́n Madrenas, Michelina Iacovino, , Paul J. Mathews

This paper describes a novel mouse model of Ataxia Telangiectasia with a nonsense mutation in Atm, showing ataxia, cerebellar defects, and potential therapeutic response to SMRT compounds.

eLife · Nov 1, 2021Peer-reviewedNeuroscience