Jonathan D. Cooper

BioMedGraphica integrates biomedical knowledge into a unified graph and introduces a Textual-Numeric Graph structure for multi-omics analysis.

The paper introduces MACS-Calling Cards to map astrocyte-specific TF occupancy in vivo and finds BMAL1 binding is redistributed in a neurodegenerative disease model due to loss of cooperative TF interactions.

This paper shows that CLN3 disease causes enteric nervous system degeneration in humans and mice, which can be prevented by neonatal gene therapy in mice.

This study shows that chronic cannabidiol treatment delays or prevents seizures in a mouse model of CLN2 disease without affecting traditional neuroimmune markers.

The paper shows that reducing heparan sulfate in cerebrospinal fluid reflects brain neuron correction in Sanfilippo B mice through targeted enzyme delivery.

This study investigates the role of GABAergic interneurons in seizure progression and mortality in CLN2 disease mice, finding that interneuron dysfunction contributes to epileptic seizures and death.

OmniCellAgent autonomously retrieves and analyzes scRNA-seq datasets to generate structured reports and hypotheses across disease settings.

This study investigates white matter injury in Sanfilippo disease using mouse models and human samples, revealing demyelination and specific MRI markers for disease progression.

This paper shows gene therapy prevents bowel motility issues and enteric neuron loss in mouse models of lysosomal storage diseases.

This study examines the effects of chronic CBD in a mouse model of neuroinflammation, neurodegeneration, and seizures, finding reduced astrocytosis and microgliosis but no impact on seizures or neuron survival.

This study genetically corrects iPSC-derived neural stem cells to deliver a modified NAGLU enzyme, reducing disease pathology in Sanfilippo B mice.

This study identifies novel disease phenotypes in Cln2R207X mice, including cortical interneuron loss and seizure generation, providing insights into CLN2 disease pathogenesis.

This study shows that rhNAGLU-IGF2 treatment improves disease markers, behavior, and survival in Sanfilippo B mice and dogs.

The paper develops a method using adeno-associated virus vectors to generate somatic-transgenic mice for non-invasive monitoring of signaling pathways in disease models.