Dynamics of the B-Cell gene regulatory network in differentiation determine evolutionary trajectories of childhood leukaemogenesis
Matthieu Bouguéon, Jason P. Wray, Tariq Enver, Benjamin A. Hall
This study models B-cell differentiation and leukaemogenesis using a logical framework to show how mutation timing and order affect disease progression in BCP-ALL.
bioRxiv · May 25, 2026 · PreprintCancer Biology