Cancer BiologybioRxivPreprint
Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in bone
Hirokazu Shimizu, Lei Wang, Masumi Tsuda…·Shinya Tanaka
This study identifies TIMELESS as a critical regulator of metastasis-initiating cell survival and reawakening in bone, with a metabolic inhibitor showing promise for therapeutic intervention.
DOI 10.1101/2025.03.18.643632