MECP2 duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: neural mappings to patients with autism
Dan-Chao Cai, Zhiwei Wang, Tingting Bo, Shengyao Yan, Zhaowen Liu, Kristina Zeljic, Xiaoyu Chen, Yafeng Zhan, Yasong Du, Jing Cang, Guang‐Zhong Wang, Guang-Zhong Wang, Jie Zhang, Qiang Sun, Zilong Qiu, , Zheng Wang
The paper identifies shared circuit-level abnormalities between MECP2 transgenic monkeys and a subgroup of human autism patients, highlighting the need for a multimodal approach to study genetic effects in a primate model.
Journal of Neuroscience · Apr 8, 2020Peer-reviewedNeuroscience