Cancer BiologyThe Journal of ImmunologyPeer-reviewed
The Aryl Hydrocarbon Receptor Controls IFNγ-Induced Immune Checkpoints PD-L1 and IDO via the JAK/STAT Pathway in Lung Adenocarcinoma
Megan Snyder, Zhongyan Wang, Brian Lara…·David H. Sherr
This study shows the aryl hydrocarbon receptor (AhR) mediates IFNγ-induced PD-L1 and IDO1 in lung adenocarcinoma via JAK/STAT, leading to immunosuppression and tumor growth.