REV-ERBalpha mediates complement expression and circadian regulation of microglial synaptic phagocytosis
Percy Y. Griffin, Patrick W. Sheehan, Julie M. Dimitry, Chun Hua Guo, Michael F. Kanan, Jiyeon Lee, Jinsong Zhang, Erik S. Musiek
This study shows that the BMAL1-REV-ERB axis regulates complement expression and microglial synaptic phagocytosis in the hippocampus, with diurnal variation observed in wild-type mice.
eLife · Dec 1, 2020Peer-reviewedNeuroscience