Author

Julius Fredens

National University of SingaporeORCID 0000-0002-4262-9304Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ashvinath NarenderaniD· 1 shared Carl O. MarshiD· 1 shared Fabian WillenborgiD· 1 shared Pramila Baban GhodeiD· 1 shared Shujian OngiD· 1 shared Shuxuan LaoiD· 1 shared Tobias V. EdeniD· 1 shared Wen Shan YewiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperSynthetic Biology

Ashvinath NarenderanORCID

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1 paper

Recent·Most cited

Accelerated evolution of whole gene clusters by an engineered lytic phage system in E. coli

Shujian Ong, Pramila Baban Ghode, Ashvinath Narenderan, Shuxuan Lao, Fabian Willenborg, Tobias V. Eden, Carl O. Marsh, Wen Shan Yew, Julius Fredens

The paper develops a phage-based system for accelerating the evolution of large gene clusters in E. coli, achieving significant improvements in tigecycline resistance and biomass production.

Nature Microbiology · May 1, 2026Peer-reviewedSynthetic Biology