Synthetic BiologyNature MicrobiologyPeer-reviewed
Accelerated evolution of whole gene clusters by an engineered lytic phage system in E. coli
Shujian Ong, Pramila Baban Ghode, Ashvinath Narenderan…·Julius Fredens
The paper develops a phage-based system for accelerating the evolution of large gene clusters in E. coli, achieving significant improvements in tigecycline resistance and biomass production.
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