Material-driven fibronectin assembly enables low-dose BMP-2 to regenerate structurally mature bone in critical-sized load-bearing defects
Oihane Mitxelena-Iribarren, Emma Muinos-Lopez, Leire Iturriaga, Irati Aiestaran-Zelaia, Daniel Werner, Jonathan Anthony Williams, Vineetha Jayawarna, Penelope Monica Tsimbouri, Tania Lopez-Martinez, Rafael Llombart- Blanco, Oliver Spaeker, Laura Zorzetto, Wolfgang Wagermaier, Sophie Anuth, Jussi-Petteri Suuronen, , Amaia Cipitria
This study shows that PEA-coated monetites functionalized with fibronectin and low-dose rhBMP-2 promote structurally mature bone regeneration in critical-sized defects.
bioRxiv · Nov 3, 2026 · PreprintBioengineering