Author

Robert A. Pearlstein

Novartis (Switzerland)ORCID 0000-0002-4313-8136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 3 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

Gianluca SelvaggioiD· 2 shared Hongbin WaniD· 2 shared Vibhas Aravamuthan· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

3 top collaborators · 2 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSystems Biology

Gianluca SelvaggioORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Probing cellular arrhythmogenesis using the O'Hara-Rudy model of the undiseased human ventricular cardiomyocyte

Gianluca Selvaggio, Hongbin Wan, Robert A. Pearlstein

This paper uses the O'Hara-Rudy model to study how different perturbations affect ventricular action potential morphology and arrhythmogenesis in midmyocytes.

bioRxiv · Nov 15, 2020 · PreprintSystems Biology

Probing the dynamic structure-function and structure-free energy relationships of the corona virus main protease with Biodynamics theory

Hongbin Wan, Vibhas Aravamuthan, Robert A. Pearlstein

The paper applies Biodynamics theory to study the dynamic structural changes and energy relationships in SARS-CoV-2 Mpro during substrate-induced activation and inhibition.

ACS Pharmacology & Translational Science · Nov 6, 2020Peer-reviewedSystems Biology

Biodynamics: A novel quasi-first principles theory on the fundamental mechanisms of cellular function/dysfunction and the pharmacological modulation thereof

Gianluca Selvaggio, Robert A. Pearlstein

The paper introduces a theoretical framework called biodynamics to explain cellular function and dysfunction through molecular analog computing and its pharmacological implications.

PLoS ONE · Nov 1, 2018Peer-reviewedSystems Biology