Author

Alexander C. Y. Foo

University of OttawaORCID 0000-0002-4331-2085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Angela Matyas· 1 shared Ariela Vergara‐JaqueiD· 1 shared Ikhuosho Asikhia· 1 shared Natalie K. GotoiD· 1 shared Samantha K. Sarkar· 1 shared Tanja Kosenko· 1 shared Thomas A. LagaceiD· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Angela Matyas

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1 paper

Recent·Most cited

A transient amphipathic helix in the PCSK9 prodomain facilitates low-density lipoprotein binding

Samantha K. Sarkar, Alexander C. Y. Foo, Angela Matyas, Ikhuosho Asikhia, Tanja Kosenko, Natalie K. Goto, Ariela Vergara‐Jaque, Thomas A. Lagace

This study identifies a transient amphipathic helix in PCSK9's prodomain that facilitates LDL binding, with mutations affecting this structure altering binding affinity and activity.

Journal of Biological Chemistry · Jan 16, 2020Peer-reviewedMolecular Biology