HKDC1 contributes to aberrant lysosome-mitochondria contact in Niemann-Pick disease type C
Raffaele Pastore, Jack Stanley, Szilvia Kiraly, Christelle Dubois, Jlenia Monfregola, Antonio DE LUCA, Germano Guerra, Mark Skehel, Andrea Ballabio, Frances M. Platt, Emily R. Eden
This study establishes isogenic NPC1 and NPC2 models to reveal that HKDC1 regulates mitochondrial-lysosome contact in NPC1-deficient cells.
bioRxiv · Jun 2, 2026 · PreprintCell Biology