Fabienne McClanahan Lucas

This study identifies Sema4A as an extrinsic factor that protects myeloid-biased HSCs from inflammatory stress, preserving functional diversity in the hematopoietic stem cell pool.

The paper describes a clinicopathologic approach and tools for diagnosing APL with TTMV::RARA fusion using NGS assays, identifying four cases with poor treatment outcomes.

DeepHeme is a convolutional neural network trained on bone marrow single-cell images that achieves high accuracy in classifying hematologic cell types, outperforming human experts.