Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool
Dorsa Toghani, Sanika Gupte, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani, Christian S. Burns, David M. Gravano, Stefan Radtke, Hans‐Peter Kiem, Sonia Rodrı́guez, Nadia Carlesso, Amogh Pradeep, Alexis Georgiades, Fabienne McClanahan Lucas, , Lev Silberstein
This study identifies Sema4A as an extrinsic factor that protects myeloid-biased HSCs from inflammatory stress, preserving functional diversity in the hematopoietic stem cell pool.
Nature Aging · Jan 29, 2025Peer-reviewedCell Biology