LINE-1 retrotransposition is a recurrent cause of MET exon 14 skipping in cancer
Jennifer A. Karlow, Callan O'connor, Radwa Raed Sharaf, Dean C. Pavlick, Andrej J. Savol, Christopher Darcy, Akshay Kakumanu, William Camara, Matthew Walsh, Tyler Janovitz, Michael J. Kelley, Christine N. Serway, Jerry W. Mitchell, Julia Andrea Elvin, Meagan Montesion, , Garrett Michael Frampton
The paper identifies LINE-1 retrotransposition as a cause of MET exon 14 skipping in cancer, leading to actionable mutations.
bioRxiv · Feb 20, 2026 · PreprintCancer Biology