Author

Wen‐Yi Huang

Division of Cancer Epidemiology and GeneticsORCID 0000-0002-4440-3368Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:GWAS / association mapping· 4 Assay:bulk RNA-seq· 2 Assay:GWAS summary statistics· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Stephen Jacob ChanockiD· 5 shared David V. ContiiD· 4 shared Mitchell J. MachielaiD· 4 shared Neal D. FreedmaniD· 4 shared Sonja I. BerndtiD· 4 shared Christopher A. HaimaniD· 3 shared Hans G. LiljaiD· 3 shared John P. ShelleyiD· 3 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersGenetic & Genomic Medicine

Stephen Jacob ChanockORCID

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5 papers

Recent·Most cited

Genetic & Genomic MedicineHuman Genetics and Genomics AdvancesPeer-reviewedJun 6, 2024

Transcriptome-Wide Association Analysis Identifies Novel Candidate Susceptibility Genes for Prostate-Specific Antigen Levels in Men Without Prostate Cancer

Dorothy M. Chen, Ruocheng Dong, Linda Kachuri…·Rebecca E. Graff

4 citations

humanbulk RNA-seq

Genetic & Genomic MedicinemedRxivPreprintOct 27, 2023

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction

Thomas J. Hoffmann, Rebecca E. Graff, Ravi Madduri…·John S. Witte

This study identifies 447 new genetic variants associated with prostate-specific antigen levels across multiple ancestries and shows improved cross-ancestry prediction of PSA, with implications for personalized prostate cancer screening.

3 citations

humanGWAS summary statistics

Genetic & Genomic MedicineNature MedicinePeer-reviewedJun 1, 2023

Genetically Adjusted PSA Levels for Prostate Cancer Screening

Linda Kachuri, Thomas J. Hoffmann, Yu Jiang…·John S. Witte

This study develops a polygenic score to adjust PSA levels, improving the detection of aggressive prostate cancer while reducing unnecessary biopsies.

80 citationstop 4%

humanbulk RNA-seq

Genetic & Genomic MedicinemedRxivPreprintJan 28, 2023

Population analyses of mosaic X chromosome loss identify genetic drivers and widespread signatures of cellular selection

Aoxing Liu, Giulio Genovese, Yajie Zhao…·Mitchell J. Machiela

This study identifies genetic drivers and cellular selection signatures of mosaic X chromosome loss in women using large-scale population data and polygenic scores.

7 citations

humanwhole-genome sequencing

Genetic & Genomic MedicineGutPeer-reviewedFeb 25, 2021

Genetic architectures of proximal and distal colorectal cancer are partly distinct

Jeroen R. Huyghe, Tabitha A. Harrison, Stephanie A. Bien…·Rachel Pearlman

This study identifies 13 new genetic loci specific to proximal or distal colorectal cancer subtypes, revealing partly distinct genetic architectures for these tumor locations.

80 citations

humanGWAS summary statistics