Xiaozhi Fu

Cross-family learning transfers thermal adaptation between enzymes

This paper shows that thermal adaptation can be transferred between unrelated enzymes using a generative framework, improving thermostability without evolutionary homology.

Single Distal Mutation Enhances Activity of known PETases via Stabilisation of PET-binding

The paper reports an engineered PETase, Fast_2.9, with enhanced activity and stability for PET degradation, identified through high-throughput screening of PET nanoparticles.

Supervised generative design of regulatory DNA forgene expression control

This paper introduces ExpressionGAN, a deep learning model that generates functional regulatory DNA with specified expression levels, outperforming random mutagenesis approaches.