Mathias Gautel

The paper designs and validates a de novo protein binder for the titin M10 domain, demonstrating its utility in fluorescence microscopy without antibodies.

The paper presents a framework for interpreting TTN missense variants by integrating clinical, computational, and functional evidence, identifying two variants as likely pathogenic.

This study investigates how truncating variants in the ttn.2 gene affect cardiac and skeletal muscle function in zebrafish, showing location-specific differences in disease severity and phenotypes.

TITINdb2 expands variant annotation and structural information for titin protein variants associated with myopathies.

The paper reports an engineered PETase, Fast_2.9, with enhanced activity and stability for PET degradation, identified through high-throughput screening of PET nanoparticles.

The paper shows that PLN pentamers act as noise-filters in β-adrenergic signaling by regulating monomer phosphorylation and stabilizing SERCA activity despite PKA activity fluctuations.