James Frederick Meschia

Neuroanatomical Basis of Coma in Acute Ischemic Stroke

This study identifies brainstem and thalamus lesions as necessary and sufficient for coma in acute ischemic stroke, highlighting lesion location over volume in coma pathogenesis.

MRI Radiomic Signature of White Matter Hyperintensities Is Associated with Clinical Phenotypes

This paper develops a radiomic signature from T2-FLAIR MRI images to predict white matter hyperintensities burden and links it to clinical phenotypes.

Sex-specific lesion topographies explain outcomesafter acute ischemic stroke

This study identifies sex-specific lesion patterns in acute ischemic stroke that correlate with stroke severity, highlighting differences in lesion distribution between men and women.

RNF213 variation, a broader role in neurovascular disease in Caucasian and Japanese populations

The paper investigates RNF213 variation's role in neurovascular diseases across Caucasian and Japanese populations, finding linkage disequilibrium between SLC26A11 and RNF213 variants associated with ischemic stroke and aneurysms.

White Matter Hyperintensity Quantification in Large-Scale Clinical Acute Ischemic Stroke Cohorts - The MRI-GENIE Study

The paper presents an automated pipeline for quantifying white matter hyperintensity in acute ischemic stroke cohorts, showing improved accuracy and enabling large-scale analysis.