Author
University of VirginiaORCID 0000-0001-9386-4091Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Wei‐Min Chen, Ani W Manichaikul, Suna Önengüt-Gümüşcü, Bradford B. Worrall, Stephen S. Rich
The paper introduces SECRET, a method to develop polygenic scores for traits with limited data, showing improved prediction power over existing methods.
bioRxiv · Oct 3, 2025 · PreprintBioinformatics
Guido J. Falcone, Stacey Q Wolfe, Marialuisa Zedde, Rosario Pascarella, Jordi Jiménez-Conde, Marta Vallverdú-Prats, Joan Jiménez-Baladó, Alessandro Pezzini, Sandra Rossi, Rustam Al‐Shahi Salman, Neshika Samarasekera, Ramin Zand, Jiaying Li, Christina Jern, Daniel Strbian, , the ERICH-Gene Investigators
ERICH-GENE collects and analyzes genomic and neuroimaging data from over 10,000 multi-ethnic ICH cases to identify genetic risk factors and trans-ethnic variation in ICH.
medRxiv · Jun 11, 2025 · PreprintGenetic & Genomic Medicine
Livia Parodi, Mary E. Comeau, Marios K. Georgakis, Ernst Mayerhofer, Jaeyoon Chung, Guido J. Falcone, Rainer Malik, Stacie L Demel, Bradford B. Worrall, Sebastian Koch, Fernando Daniel Testai, Steven J. Kittner, Jacob L. McCauley, Christiana E. Hall, Douglas J. Mayson, , Christopher D. Anderson
The paper performs deep resequencing of the 1q22 locus in non-lobar ICH cases and controls to identify causal variants and mechanisms.
Annals of Neurology · Oct 4, 2023Peer-reviewedGenetic & Genomic Medicine
Martin Bretzner, Anna Katharina Bonkhoff, Markus D. Schirmer, Sung‐Min Hong, Adrian Vasile Dalca, Kathleen Donahue, Anne‐Katrin Giese, Mark R. Etherton, Pamela M. Rist, Marco Nardin, Razvan Valentin Marinescu, Clinton J. Wang, Robert William Regenhardt, X. Leclerc, Renaud Lopes, , Natalia S. Rost
This paper develops a radiomic signature from T2-FLAIR MRI images to predict white matter hyperintensities burden and links it to clinical phenotypes.
Frontiers in Neuroscience · Jul 12, 2021Peer-reviewedNeuroscience
Anna Katharina Bonkhoff, Markus D. Schirmer, Martin Bretzner, Sung‐Min Hong, Robert William Regenhardt, Mikael Brudfors, Kathleen Donahue, Marco Nardin, Adrian Vasile Dalca, Anne‐Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, , Natalia S. Rost
This study identifies sex-specific lesion patterns in acute ischemic stroke that correlate with stroke severity, highlighting differences in lesion distribution between men and women.
bioRxiv · Sep 25, 2020 · PreprintNeuroscience
Joanna von Berg, Sander W. van der Laan, Patrick F. McArdle, Rainer Malik, Steven J. Kittner, Braxton D. Mitchell, Bradford B. Worrall, Jeroen de Ridder, Sara L. Pulit
The paper compares two phenotyping approaches for ischemic stroke subtypes and identifies a genetic risk locus for small vessel stroke using the intersect phenotype.
European Journal of Human Genetics · Feb 11, 2020Peer-reviewedGenetics
Markus D. Schirmer, Adrian Vasile Dalca, Ramesh Sridharan, Anne‐Katrin Giese, Kathleen Donahue, Marco Nardin, Steven J. T. Mocking, Elissa C. McIntosh, Petrea Frid, Johan Wassélius, John W. Cole, Lukas Holmegaard, Christina Jern, Jordi Jiménez-Conde, Robin Lemmens, , on behalf of the MRI-GENIE Investigators
The paper presents an automated pipeline for quantifying white matter hyperintensity in acute ischemic stroke cohorts, showing improved accuracy and enabling large-scale analysis.
NeuroImage Clinical · Jan 1, 2019Peer-reviewedNeuroscience
Daniel S. Tylee, Jiayin Sun, Jonathan L. Hess, Muhammad A. Tahir, Esha Sharma, Rainer Malik, Bradford B. Worrall, Andrew J. Levine, Jeremy J. Martinson, Sergey Nejentsev, Doug Speed, Annegret Fischer, Eric O. Mick, Brian Robert Walker, Andrew Crawford, , Stephen J. Glatt
The paper investigates genetic correlations between psychiatric and immune-related phenotypes using GWAS summary data, finding significant shared genetic variants.
bioRxiv · Mar 10, 2018 · PreprintBioinformatics