Towards foundation models that learn across biological scales
Jérémie Kalfon, Laura Cantini, Gabriel Peyré A
The paper introduces Xpressor, a framework for cross-scale learning in biology, improving cell-type prediction and embedding quality.
Author
Centre National de la Recherche ScientifiqueORCID 0000-0002-4477-0387Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
Recent·Most cited
Jérémie Kalfon, Laura Cantini, Gabriel Peyré A
The paper introduces Xpressor, a framework for cross-scale learning in biology, improving cell-type prediction and embedding quality.
Anna Audit, Gabriel Peyré A, Laura Cantini
The paper introduces FLOWSATATE, a trajectory inference method using time-resolved RNA labeling data to model cell fate dynamics and predict future states.
Jules Samaran, Gabriel Peyré A, Laura Cantini
CHAMPOLLION improves multi-omics integration by using regularized optimal transport to align unpaired cells and reveal cross-modal relationships, outperforming existing methods with fewer paired cells.
Jérémie Kalfon, Gabriel Peyré A, Laura Cantini
scPRINT-2 is a single-cell foundation model pre-trained on 350 million cells across 16 organisms, achieving state-of-the-art performance in expression denoising, cell embedding, and cell type prediction.
Jérémie Kalfon, Jules Samaran, Gabriel Peyré A, Laura Cantini
scPRINT pre-trains on 50 million cells to predict gene networks, outperforming existing methods in inference and zero-shot tasks.
Jules Samaran, Gabriel Peyré A, Laura Cantini
scConfluence improves single-cell diagonal integration by combining autoencoders with regularized Inverse Optimal Transport, outperforming existing methods in three biological applications.
Geert-Jan Huizing, Jules Samaran, Daniele Capocefalo…·Laura Cantini
The paper introduces STORIES, a method for learning cell fate landscapes from spatial transcriptomics data, showing improved spatial coherence in neural regeneration and gliogenesis analyses.
Geert-Jan Huizing, Ina Maria Deutschmann, Gabriel Peyré A, Laura Cantini
Mowgli integrates paired single-cell multi-omics data using a combination of NMF and OT, improving clustering and interpretability, and is benchmarked against state-of-the-art methods.
Geert-Jan Huizing, Gabriel Peyré A, Laura Cantini
This paper introduces Optimal Transport as a cell-cell similarity metric for single-cell omics data, showing improved clustering performance across multiple datasets.