Daniele Capocefalo

This study shows that CENP-A, a centromeric histone variant, epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cells through non-centromeric mechanisms.

The paper uses combinatorial CRISPR-Cas9 perturbations in brain organoids to uncover regulatory hierarchies of human-specific genes involved in cortical evolution.

This study identifies IL-23's role in shaping the functional plasticity of human MAIT cells, revealing its impact on autoimmunity and cytotoxic functions through AP-1 transcription factors.

The paper introduces STORIES, a method for learning cell fate landscapes from spatial transcriptomics data, showing improved spatial coherence in neural regeneration and gliogenesis analyses.

The paper curates causal gene-protein interactions linked to autism and develops tools to explore their functional relationships with phenotypes and pathways.

This study investigates how 7q11.23 CNVs affect protein synthesis and neuronal excitability in neurodevelopmental disorders using patient-derived neurons and multi-omics approaches.

This study investigates how KMT2D mutations in Kabuki Syndrome disrupt neuronal function through chromatin and transcriptional changes, independent of H3K4me1.