Developmental BiologybioRxivPreprint
Proteogenomic Reprogramming to a Functional Human Totipotent Stem Cell State via a PARP-DUX4 Regulatory Axis
Ludovic Zimmerlin, Ariana M. Angarita, Tea Soon Park…·Elias T. Zambidis
This paper demonstrates that inhibiting PARP1 and Tankyrases in human pluripotent stem cells reprograms them to a totipotent state with lineage-specific gene expression and proteomic changes, mimicking early embryonic development.
DOI 10.1101/2024.06.14.598510