Author

Isabella Vegas

Johns Hopkins UniversityORCID 0009-0005-2437-7130Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Achim A. JungbluthiD· 1 shared Andrea M. GazzoiD· 1 shared Anthony K. L. LeungiD· 1 shared Anton Mikhailovich SafonoviD· 1 shared Antonio MarraiD· 1 shared Ariana M. Angarita· 1 shared Avantika GuptaiD· 1 shared Bojana StefanovskaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Achim A. JungbluthORCID

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2 papers

Recent·Most cited

Cancer BiologyNature GeneticsPeer-reviewedMay 16, 2025

APOBEC3 mutagenesis drives therapy resistance in breast cancer

Avantika Gupta, Andrea M. Gazzo, Pier Selenica…·Sarat Chandarlapaty

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

51 citationstop 1%

humanwhole-genome sequencing

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Developmental BiologybioRxivPreprintJun 14, 2024

Proteogenomic Reprogramming to a Functional Human Totipotent Stem Cell State via a PARP-DUX4 Regulatory Axis

Ludovic Zimmerlin, Ariana M. Angarita, Tea Soon Park…·Elias T. Zambidis

This paper demonstrates that inhibiting PARP1 and Tankyrases in human pluripotent stem cells reprograms them to a totipotent state with lineage-specific gene expression and proteomic changes, mimicking early embryonic development.

DOI 10.1101/2024.06.14.598510

humanproteomics

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