Tea Soon Park

This paper demonstrates that inhibiting PARP1 and Tankyrases in human pluripotent stem cells reprograms them to a totipotent state with lineage-specific gene expression and proteomic changes, mimicking early embryonic development.

This paper shows that reprogramming diabetic fibroblasts into naive hiPSC using tankyrase inhibitors improves vascular progenitor generation and revascularization in ischemic retinas.