Identifying cross-lineage dependencies of cell-type specific regulators in gastruloids
Luca Braccioli, Teun van den Brand, Noemí Alonso Saiz, Charis Fountas, Patrick H. N. Celie, Justina Kazokaitė-Adomaitienė, Elzo de Wit
The paper identifies cross-lineage dependencies in gastruloid development by analyzing single-cell chromatin accessibility, showing that paraxial mesoderm is required for spinal cord formation through cell-cell interactions.
bioRxiv · Nov 1, 2022 · PreprintSystems Biology