Luca Braccioli

This study shows CTCF has dual roles in early mammalian development: promoting morphogenesis through promoter binding early on and enabling correct development via looping later.

The paper investigates how CTCF binding sites affect the regulatory landscape of the mouse Sox2 locus by relocating them and measuring their impact on gene expression.

This study shows ZNF143 regulates nuclear-encoded mitochondrial genes and is essential for development, without affecting chromatin looping or CTCF interactions.

This study shows that cohesin is not always necessary for enhancer function, as some enhancers can act independently through synergy or insulators.

The paper identifies cross-lineage dependencies in gastruloid development by analyzing single-cell chromatin accessibility, showing that paraxial mesoderm is required for spinal cord formation through cell-cell interactions.

This study shows WAPL maintains dynamic cohesin at lineage-specific regulatory regions in mouse embryonic stem cells, which is essential for gene expression and pluripotency.