Teun van den Brand

This study shows that DOT1L maintains CD8 T cell identity and restricts their cytotoxic potential by preventing NK-cell features and enhancing anti-tumor reactivity.

The paper identifies Fpt1 as a chromatin-associated regulator that promotes RNA Polymerase III eviction from tRNA genes in response to nutrient changes in yeast.

The paper identifies that SOX2 maintains chromatin accessibility at regulatory sites that drive gene expression, distinguishing them from non-activating binding sites.

This study identifies asymmetrically expressed genes in the mouse cardiac crescent during left-right symmetry breaking using single-cell RNA sequencing and validates their expression patterns.

The paper identifies cross-lineage dependencies in gastruloid development by analyzing single-cell chromatin accessibility, showing that paraxial mesoderm is required for spinal cord formation through cell-cell interactions.

GENOVA is an R-package for analysing Hi-C data, demonstrating that cohesin subunits SA1 and SA2 differentially affect loop formation and genome compartmentalisation.

This study shows WAPL maintains dynamic cohesin at lineage-specific regulatory regions in mouse embryonic stem cells, which is essential for gene expression and pluripotency.