Small molecule agonists of 8-oxoguanine DNA glycosylase, OGG1
Michael M. Luzadder, Irina G. Minko, Samantha A. Moellmer, Naoto N. Tozaki, Paweł Jaruga, Miral Dizdaroğlu, Haihong Jin, Jordan Devereaux, Aaron Nilsen, R. Stephen Lloyd, Amanda K. McCullough
This paper identifies small molecule agonists of OGG1 that enhance its catalytic activity and reduce oxidative stress in OGG1-deficient cells.
bioRxiv · Jan 31, 2026 · PreprintBiochemistry