Author

Dong Yan Zhang

Pennsylvania State UniversityORCID 0000-0002-4513-3283Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:diffusion model· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:protein structure· 1

Frequent Co-Authors

Jian WangiD· 2 shared Nikolay V. DokholyaniD· 2 shared Feng DingiD· 1 shared Gangtong HuangiD· 1 shared Sara Langberg· 1 shared Shreshty BudakotiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersBioinformatics

Jian WangORCID

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2 papers

Recent·Most cited

A Diffusion-Based Framework for Designing Molecules in Flexible Protein Pockets

Jian Wang, Dong Yan Zhang, Shreshty Budakoti, Nikolay V. Dokholyan

YuelDesign generates molecules for flexible protein pockets using a diffusion framework, producing drug-like molecules with diverse functional groups and comparable docking energies to native ligands.

bioRxiv · May 27, 2025 · PreprintBioinformatics

APOE regulates the transport of GM1

Dong Yan Zhang, Jian Wang, Gangtong Huang, Sara Langberg, Feng Ding, Nikolay V. Dokholyan

This study shows APOE regulates GM1 transport, which influences Aβ aggregation, linking APOE to Alzheimer's disease etiology.

bioRxiv · Apr 2, 2024 · PreprintNeuroscience