Author

Joshua McWhirt

University of California, IrvineORCID 0000-0002-4524-0716Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Gregory J. BreweriD· 2 shared Ricardo A. Santana-MartíneziD· 2 shared Balam Benítez-MataiD· 1 shared Michelle A. DigmaniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersNeuroscience

Gregory J. BrewerORCID

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2 papers

Recent·Most cited

Treatment of age-related decreases in GTP levels restores endocytosis and autophagy

Ricardo A. Santana-Martínez, Joshua McWhirt, Gregory J. Brewer

The paper shows that restoring GTP levels in aged neurons improves endocytosis and autophagy, reducing Aβ aggregates and oxidative damage.

GeroScience · Aug 2, 2025Peer-reviewedNeuroscience

AD-genes and Aging Increase Count and Size of Lipid Droplets, Accompanied by Accumulation of Neutral Lipids Across Compartments in Hippocampal Neurons.

Balam Benítez-Mata, Joshua McWhirt, Ricardo A. Santana-Martínez, Gregory J. Brewer, Michelle A. Digman

This study examines lipid polarity and droplet changes in hippocampal neurons across aging and Alzheimer's disease models, finding altered lipid dynamics in AD-transgenic mice.

bioRxiv · Jul 1, 2025 · PreprintBiophysics