Maurice Filo

This paper develops a control-theoretic framework for engineering closed-loop cell-based therapies using nullgram profiling and a digital twin platform to achieve robust regulation of cellular behavior.

This paper presents three biomolecular anti-windup topologies to prevent instability in integral controllers by linking control-theoretic strategies to chemical reaction networks.

The paper demonstrates how nonlinear sequestration reactions in antithetic integral controllers can improve dynamic performance and reduce variability while maintaining robust adaptation.

This paper develops a framework using split inteins to design and test biomolecular controllers that achieve robust perfect adaptation in mammalian cells.

This paper designs biomolecular PID controllers to achieve robust perfect adaptation and improved dynamic performance in synthetic biology systems.

This paper introduces synthetic integral and proportional-integral feedback controllers in mammalian cells to achieve robust perfect adaptation, showing improved stability and reduced variability.