Ching-Hsiang Chang

This paper develops a control-theoretic framework for engineering closed-loop cell-based therapies using nullgram profiling and a digital twin platform to achieve robust regulation of cellular behavior.

This paper develops a framework using split inteins to design and test biomolecular controllers that achieve robust perfect adaptation in mammalian cells.

This paper introduces synthetic integral and proportional-integral feedback controllers in mammalian cells to achieve robust perfect adaptation, showing improved stability and reduced variability.