Electric Field-Induced Destabilization and Surface Modulation of Aβ42 Fibrils in Molecular Simulations: Theoretical Implications for DC Stimulation in Alzheimer's Disease
Fran Bačić Toplek, Natale Vincenzo Maiorana, Matteo Guidetti, Sara Renata Francesca Marceglia, Riccardo Capelli, Alberto Priori, Carlo Camilloni
This paper uses molecular dynamics simulations to study how static electric fields affect Aβ42 fibrils, showing they destabilize fibrils by altering surface properties and reducing secondary nucleation.
bioRxiv · Sep 24, 2025 · PreprintBiophysics