Author

Fran Bačić Toplek

University of MilanORCID 0000-0002-8331-0885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Carlo CamilloniiD· 2 shared Riccardo CapelliiD· 2 shared Alberto PrioriiD· 1 shared Bruno SteganiiD· 1 shared Camilla ArdizzoneiD· 1 shared Kresten Lindorff‐LarseniD· 1 shared Luís Borges-AraújoiD· 1 shared Matteo GuidettiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

Carlo CamilloniORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Assessing multi-eGO Predictions of PDZ2-Peptide Binding across Mutations

Camilla Ardizzone, Bruno Stegani, Fran Bačić Toplek, Stefano Gianni, Riccardo Capelli, Carlo Camilloni

This study evaluates multi-eGO's ability to predict PDZ2-peptide binding changes across mutations, showing good thermodynamic agreement but limited kinetic accuracy.

bioRxiv · Sep 14, 2026 · PreprintBiochemistry

Towards transferable explicit-solvent coarse-grained models for biomolecular condensates

Fran Bačić Toplek, Luís Borges-Araújo, Kresten Lindorff‐Larsen, Ralf Everaers, Paulo C. T. Souza, Tatiana I. Morozova

The paper improves a coarse-grained model for biomolecular condensates by enhancing dilute-state properties, showing better condensed-phase behavior but not full quantitative accuracy.

bioRxiv · Aug 29, 2026 · PreprintBiophysics

Electric Field-Induced Destabilization and Surface Modulation of Aβ42 Fibrils in Molecular Simulations: Theoretical Implications for DC Stimulation in Alzheimer's Disease

Fran Bačić Toplek, Natale Vincenzo Maiorana, Matteo Guidetti, Sara Renata Francesca Marceglia, Riccardo Capelli, Alberto Priori, Carlo Camilloni

This paper uses molecular dynamics simulations to study how static electric fields affect Aβ42 fibrils, showing they destabilize fibrils by altering surface properties and reducing secondary nucleation.

bioRxiv · Sep 24, 2025 · PreprintBiophysics