Author

Jacqueline M. Otto

Regeneron (United States)ORCID 0000-0002-4583-2076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:GWAS / association mapping· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alan R. ShuldineriD· 1 shared Andreja AvberšekiD· 1 shared Ariane H. Ayer· 1 shared Aris BarasiD· 1 shared Dana B. HancockiD· 1 shared David J. LedereriD· 1 shared Deepika SharmaiD· 1 shared Eli A. StahliD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alan R. ShuldinerORCID

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2 papers

Recent·Most cited

Rare coding variants in CHRNB2 reduce the likelihood of smoking

Veera Manikandan Rajagopal, Kyoko Watanabe, Joelle S. Mbatchou, Ariane H. Ayer, Peter Quon, Deepika Sharma, Michael D. Kessler, Kavita Praveen, Sahar Gelfman, Neelroop Parikshak, Jacqueline M. Otto, Suying Bao, Shek Man Chim, Elias Pavlopoulos, Andreja Avberšek, , Giovanni Coppola

The paper identifies rare coding variants in CHRNB2 associated with reduced smoking likelihood and links them to downstream smoking-related phenotypes.

medRxiv · Oct 27, 2022 · PreprintGenetic & Genomic Medicine

Genetic architecture of four smoking behaviors using partitioned h2SNP.

Luke M. Evans, Seon-Kyeong Jang, Dana B. Hancock, Marissa A. Ehringer, Jacqueline M. Otto, Scott I. Vrieze, Matthew C. Keller

The paper estimates SNP-based heritability for four smoking behaviors using partitioned h2SNP in the UK Biobank, finding modest heritability and significant contributions from low-frequency variants.

Addiction · Feb 23, 2021Peer-reviewedGenetic & Genomic Medicine