Seon-Kyeong Jang

Comprehensive gene heritability estimation reveals the genetic architecture of rare coding variants underlying complex traits

This paper introduces FLEX, a method for estimating gene-level heritability from whole-exome sequencing data, showing rare coding variants contribute significantly to complex trait heritability.

Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions

The paper investigates why carriers of pathogenic variants in monogenic metabolic conditions show variable disease severity, finding support for variant effect sizes, polygenic backgrounds, and epistasis.

Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

Genetic architecture of four smoking behaviors using partitioned h2SNP.

The paper estimates SNP-based heritability for four smoking behaviors using partitioned h2SNP in the UK Biobank, finding modest heritability and significant contributions from low-frequency variants.