Sandrine Gonin-Giraud

Mechanistic stochastic gene regulatory network inference on neuroblastoma tumoroid scRNA-seq predicts TCF4 as a hub whose loss slows chromaffin-to-sympathoblast progression, supported by JQ1 treatment ex vivo.

This study uses a multiscale agent-based model to show that short-range diffusive signaling among stem cells is critical for reproducing the spatial structure of neuroblastoma tumoroids.

The paper introduces a Design of Experiment strategy to refine Gene Regulatory Networks by selecting informative perturbations and validating predictions against experimental data.

The paper identifies drugs that modulate stochastic gene expression and shows their impact on erythroid differentiation.

WASABI infers causal gene regulatory networks from time-stamped single-cell data, revealing a distributed network structure without hub genes in avian erythroid differentiation.