Arnaud Bonnaffoux

The paper identifies a dynamic gene regulatory network in Duchenne muscular dystrophy that controls cell fate decisions and shows how disease mutations disrupt this network.

The paper introduces a Design of Experiment strategy to refine Gene Regulatory Networks by selecting informative perturbations and validating predictions against experimental data.

VData extends the AnnData format to handle large time-stamped datasets by adding a third dimension for time, enabling efficient storage and manipulation.

WASABI infers causal gene regulatory networks from time-stamped single-cell data, revealing a distributed network structure without hub genes in avian erythroid differentiation.